A1 — Confirmed Human Carcinogen, on the weight of evidence from epidemiologic studies. A2 — Suspected Human Carcinogen: human data adequate but conflicting or insufficient, or carcinogenic in animals by a route or mechanism relevant to workers. A3 — Confirmed Animal Carcinogen with Unknown Relevance to Humans: carcinogenic in animals at high dose by a route that may not be relevant, with no confirmed human risk. A4 — Not Classifiable: concern exists but there is not enough data to assess. A5 — Not Suspected as a Human Carcinogen, on the basis of adequate negative epidemiology. The absence of a category does NOT mean the substance is safe — ACGIH assigns no designation where no carcinogenicity data exist at all, so a blank means untested and A5 means tested and cleared. For A1, A2 and A3, Appendix A requires exposure by all routes to be controlled to levels as low as possible below the TLV; for an A1 carcinogen with no TLV, exposure should be eliminated to the fullest extent possible.
General OH&S